RNA Details
Disease Name
silicosis
Tissue
lung
RNA Symbol
Atg5
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; qRT-PCR; Western Blot etc.
Target
NA
Pathway
NA
PubMed ID
Title
MicroRNA-205-5p targets E2F1 to promote autophagy and inhibit pulmonary fibrosis in silicosis through impairing SKP2-mediated Beclin1 ubiquitination
Year
2021
Function
"Our findings revealed that the mRNA and protein levels of Beclin1, LC3 and autophagy-related gene-5 (ATG5) were increased after treatment with CS, and Beclin1, LC3 and ATG5 increased upon combination treatment with CS and rapamycin."